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Single-molecule Fluorescence Spectroscopy of TOTO on Poly-AT and Poly-GC DNA

✍ Scribed by Benjamin P. Bowen; Jörg Enderlein; Neal W. Woodbury

Book ID
111837156
Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
105 KB
Volume
78
Category
Article
ISSN
0031-8655

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## Abstract The TAR element of HIV and the viral protein Tat form a molecular switch regulating transcriptional efficiency in HIV. We show that fluorescence correlation spectroscopy at the single molecule level is a powerful method to study the association between a Tat‐derived peptide and TAR frag