Single maxillary central incisor, holoprosencephaly, and holoprosencephaly-like phenotype
✍ Scribed by A. Richieri-Costa; Lucilene Arilho Ribeiro
- Book ID
- 101448316
- Publisher
- John Wiley and Sons
- Year
- 2006
- Tongue
- English
- Weight
- 205 KB
- Volume
- 140A
- Category
- Article
- ISSN
- 1552-4825
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✦ Synopsis
Abstract
Three patients—one with alobar holoprosencephaly and two with a holoprosencephaly‐like phenotype—are reported with no identifiable mutations. In each case, one parent had a single maxillary central incisor (SMCI). We briefly review the holoprosencephaly‐like phenotype and present a table of 25 conditions with SMCI. © 2006 Wiley‐Liss, Inc.
📜 SIMILAR VOLUMES
A holoprosencephalic child was born to a mother with a single central maxillary incisor. The infant had a median cleft lip, a flat nose with a single nostril, hypotelorism, and normal chromosomes. The head was brachycephalic and small, and computed tomography (CT) of the brain showed semilobar holop
## Abstract Holoprosencephaly (HPE) is genetically heterogeneous. Variable phenotypic manifestations within families with normal and affected patients have been attributed to the number and type of HPE gene mutations. Environmental agents may also contribute to the severity as well as the requireme