Single-fiber electromyography in limb and facial muscles in muscle-specific kinase antibody and acetylcholine receptor antibody myasthenia gravis

✍ Scribed by Maria Elena Farrugia; Robin P. Kennett; John Newsom-Davis; David Hilton-Jones; Angela Vincent

• Publisher: John Wiley and Sons
• Year: 2006
• Tongue: English
• Weight: 73 KB
• Volume: 33
• Category: Article
• ISSN: 0148-639X
• DOI: 10.1002/mus.20491

✦ Synopsis

Abstract

We examined the findings from single‐fiber electromyography in extensor digitorum communis (EDC) and orbicularis oculi (OOc) in 13 myasthenia gravis (MG) patients with muscle‐specific kinase antibodies (MuSK‐MG) and 12 MG patients with acetylcholine receptor antibodies (AChR‐MG) with similar clinical scores. More than 70% of AChR‐MG patients had abnormal jitter in both EDC and OOc, but the majority of MuSK‐MG patients had normal jitter in EDC despite abnormal jitter in OOc. These findings demonstrate clear differences between the neurophysiology of MuSK‐MG and AChR‐MG. Muscle Nerve, 2005