Single-episode photodynamic therapy and vulval intraepithelial neoplasia type III resistant to conventional therapy

✍ Scribed by H.A. Kurwa; R.J. Barlow; S. Neill

• Book ID: 104459578
• Publisher: John Wiley and Sons
• Year: 2000
• Tongue: English
• Weight: 269 KB
• Volume: 143
• Category: Article
• ISSN: 0007-0963
• DOI: 10.1046/j.1365-2133.2000.03785.x

✦ Synopsis

Background:

Photodynamic therapy (pdt) using topical 5-aminolaevulinic acid (5-ala) has been suggested as an effective and tissue-conserving method of treating carcinoma in situ of the vulva.

Objectives:

To evaluate pdt in patients with vulval intraepithelial neoplasia type iii (vin iii).

Methods:

Topical pdt was performed in six patients with vin iii. five of the six patients had persistent disease following treatment with other modalities including 5-fluorouracil cream, cryotherapy, carbon dioxide laser ablation and excision. each patient was treated once with a fluence of 150 j cm-2 using a broad-band light source (580-740 nm) 4 h after topical application of 20% 5-ala. patients were reviewed clinically at 1 month and 6 months after treatment.

Results:

All of the patients developed initial erythema of treated sites, three with subsequent erosions. all patients had clinically evident persistent vin iii at 1-month review. five patients have subsequently undergone surgical treatment and one is regularly reviewed.

Conclusions:

This small uncontrolled study indicates that, as currently administered, a single episode of topical pdt is not effective in the management of treatment-resistant vin iii.