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Single-dose kinetics of the neuroleptic drug perazine in psychotic patients

โœ Scribed by Ursula Breyer-Pfaff; K. Nill; H. W. Schied; H. J. Gaertner; H. Giedke

Publisher
Springer
Year
1988
Tongue
English
Weight
372 KB
Volume
95
Category
Article
ISSN
0033-3158

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โœฆ Synopsis

Eight male and two female unmedicated psychotic patients received 100 mg perazine orally and seven blood samples were taken within 25 h. Plasma levels of perazine and its demethylated metabolite were analyzed by HPLC with electrochemical detection. They exhibited large interindividual variations, with maximal concentrations as well as AUC values of perazine differing more than 10-fold. From the decay of plasma levels during the last 12-18 h half-lives were estimated to be between 7.5 and 16 h; they did not correlate with AUC. There was a significant positive correlation between AUC and age. Desmethylperazine was consistently present at lower concentrations than the parent drug during the first 12 h.

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