Single-breathhold four-dimensional assessment of left ventricular volumes and function using k-t BLAST after application of extracellular contrast agent at 3 Tesla
✍ Scribed by Ashraf Hamdan; Sebastian Kelle; Bernhard Schnackenburg; Ernst Wellnhofer; Eckart Fleck; Eike Nagel
- Publisher
- John Wiley and Sons
- Year
- 2008
- Tongue
- English
- Weight
- 491 KB
- Volume
- 27
- Category
- Article
- ISSN
- 1053-1807
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✦ Synopsis
Abstract
Purpose
To prospectively determine the feasibility and accuracy of a four‐dimensional (4D) k‐space over time broad‐use linear acquisition speed‐up technique (k‐t BLAST) for the evaluation of left ventricular (LV) volumes in comparison to standard multiple‐breathhold cine imaging, using a 3.0 Tesla (3T) MR system.
Materials and Methods
In 23 subjects, short‐axis cine loops completely covering the LV were acquired using conventional turbo gradient echo (GRE) imaging. Immediately after administration of gadobenate dimeglumine, a rapid single‐breathhold k‐t BLAST 4D dataset with the same coverage was acquired and reconstructed to short‐axis views. Quantitative aortic flow measurement for LV stroke volume (LVSV) was used to calibrate both techniques. For GRE and k‐t BLAST cine imaging: LV volumes, ejection fraction (EF), and blood‐to‐myocardium‐contrast (BMC) were determined.
Results
k‐t BLAST and GRE sequences showed a strong correlation for LV volumes and EF (r = 0.97–0.99; P < 0.001). Excellent agreement was also found between the LVSV determined by aortic flow measurements and LVSV assessed using GRE sequence and k‐t BLAST sequence. BMC of GRE was similar to that of k‐t BLAST cine imaging.
Conclusion
The use of the single‐breathhold 4D k‐t BLAST technique for the assessment of LV volume is feasible and accurate in 3T MRI. J. Magn. Reson. Imaging 2008;27:1028–1036. © 2008 Wiley‐Liss, Inc.