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Single blind randomized Phase III trial to investigate the benefit of a focal lesion ablative microboost in prostate cancer (FLAME-trial): study protocol for a randomized controlled trial

✍ Scribed by Irene M Lips; Uulke A van der Heide; Karin Haustermans; Emile NJT van Lin; Floris Pos; Stefan PG Franken; Alexis NTJ Kotte; Carla H van Gils; Marco van Vulpen

Book ID: 115022827
Publisher: BioMed Central
Year: 2011
Tongue: English
Weight: 414 KB
Volume: 12
Category: Article
ISSN: 1468-6708
DOI: 10.1186/1745-6215-12-255

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## Abstract ## BACKGROUND. The objective of this study was to evaluate the efficacy and safety of atrasentan (Xinlay), a selective endothelin‐A receptor antagonist, in patients with metastatic hormone‐refractory prostate cancer (HRPC). ## METHODS. This multinational, double‐blind, placebo‐contro