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Single and multiple mutations in the human cytomegalovirus UL97 gene and their relationship to the enzymatic activity of UL97 kinase for ganciclovir phosphorylation

✍ Scribed by Silvia I. Sanchez Puch; Verónica L. Mathet; Margarita Porta; María L. Cuestas; José R. Oubiña; Cristina M. Videla; Horacio E. Salomón


Book ID
113458148
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
346 KB
Volume
84
Category
Article
ISSN
0166-3542

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✍ Detlef Michel; Simone Höhn; Tobias Haller; Dou Jun; Thomas Mertens 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 96 KB

## Abstract Phenotypically, ganciclovir‐resistant human cytomegalovirus strains could be selected by aciclovir as effectively as by ganciclovir in vitro. Three clinical human cytomegalovirus isolates with different sensitivities against ganciclovir, aciclovir, foscarnet, and cidofovir, but without