The indirect effect of diet on the single-and multiple-dose pharmacokinetics of sustained-release ketoprofen was studied in 16 healthy male volunteers. In an open, cross-over design, 200 mg ketoprofen was administered as a gastric-juice-resistant, sustained-release tablet once daily during two perio
Single and multiple dose pharmacokinetics of enteric coated ketoprofen: Effect of cimetidine
โ Scribed by R. K. Verbeeck; C. L. Corman; S. M. Wallace; R. J. Herman; S. G. Ross; P. Morvan
- Publisher
- Springer
- Year
- 1988
- Tongue
- English
- Weight
- 773 KB
- Volume
- 35
- Category
- Article
- ISSN
- 0031-6970
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๐ SIMILAR VOLUMES
Ketoprofen (KT), a chiral nonsteroidal anti-inflammatory drug (NSAID), is marketed and used as a racemic mixture. In healthy volunteers, negligible differences have been reported between the plasma time courses of KT enantiomers. Using a stereospecific high-performance liquid chromatographic (HPLC)
## Abstract The effects of age and dose on the pharmacokinetics of ketoprofen were evaluated in young adult and senescent male Fischer 344 rats following intravenous administration of 2ยท5 and 10 mg kg^โ1^. Plasma concentrations were measured by HPLC and free ketoprofen determined by equilibrium dia
The effect of age on the pharmacokinetics of erythromycin was investigated by comparing its kinetic behaviour in eight young healthy adults and eight healthy elderly subjects after single and repeated oral doses of erythromycin stearate 1 g b.d. for 7 doses. The peak serum concentration and area und