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Single and bulk compression of pharmaceutical excipients: Evaluation of mechanical properties

โœ Scribed by Siaw Fung Yap; Michael J. Adams; Jonathan P.K. Seville; Zhibing Zhang

Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
521 KB
Volume
185
Category
Article
ISSN
0032-5910

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โœฆ Synopsis

The compaction of powders into tablets is widely used in the pharmaceutical industry to convert drugs, in the form of small particles, into coherent and robust metered solid dosage forms. In order to produce robust tablets with the required properties, it is essential to understand the elastic, viscoelastic and plastic properties and rupture strength of the feed particles, which can be as small as a few microns in diameter. The objective of this work is to characterise the mechanical properties of single particles using a micromanipulation diametrical compression technique and relate the parameters to the compression behaviour of powders. Mechanical parameters, such as the Young's modulus, hardness and nominal rupture stress, were thus determined for each sample. The bulk compression data of the powders were analysed to calculate the parameters of the

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