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Single-Amino Acid Substitutions Alter the Specificity and Affinity of PDZ Domains for Their Ligands †

✍ Scribed by Gee, Stephen H.; Quenneville, Stéphane; Lombardo, Christian R.; Chabot, Josée

Book ID
126087433
Publisher
American Chemical Society
Year
2000
Tongue
English
Weight
139 KB
Volume
39
Category
Article
ISSN
0006-2960

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## Abstract Breast cancer resistance protein (BCRP) is a member of ATP‐binding cassette transporters that has an N‐terminal ATP binding domain and a C‐terminal transmembrane domain (TM). Expression of wild‐type BCRP confers resistance to multiple chemotherapeutic agents such as mitoxantrone, SN‐38