Simvastatin-tacrolimus and simvastatin-cyclosporin interactions in rats

✍ Scribed by Harumi Yamada; Hajime Kotaki; Yasufumi Sawada; Tatsuji Iga

• Publisher: John Wiley and Sons
• Year: 1998
• Tongue: English
• Weight: 185 KB
• Volume: 19
• Category: Article
• ISSN: 0142-2782
• DOI: 10.1002/(sici)1099-081x(199807)19:5<279::aid-bdd101>3.0.co;2-q

✦ Synopsis

The effect of simvastatin (SV)-tacrolimus (TL) and simvastatin-cyclosporin (CyA) interactions on creatine phosphokinase levels and renal and hepatic function were investigated in rats. Animals were divided into seven groups; (1) SV (150 mg kg -1 oral) alone, (2) SV +TL (150 mg kg -1 oral+ 0.5 mg kg -1 intraperitoneal (i.p.)), ( 3) TL (0.5 mg kg -1 i.p.) alone, (4) SV+CyA (150 mg kg -1 oral+ 10 mg kg -1 oral), ( 5) CyA (10 mg kg -1 oral) alone, (6) control vehicle for oral administration, and (7) control vehicle for i.p. administration. A marked reduction in body weight and mortality was observed in the (SV +CyA) and (SV +TL) groups. Plasma creatine kinase levels in the (SV), (TL), (SV + CyA) and (SV +TL) groups, 7 days postadministration, were significantly higher compared with those before administration (p B0.05). The plasma urea nitrogen levels in the (TL), (SV + CyA) and (SV +TL) groups after 7 days of administration were significantly higher than those of the controls. In addition, a marked increase in the plasma levels of alanine and aspartate amino transferases were observed in the (SV + CyA) groups.