## Abstract Addition of nordihydroguaiaretic acid (NDGA) to the differentiation medium of C2C12 mouse myoblast cells caused severe inhibition of the formation of myotubes and suppressed differentiationβdependent elevation in the levels of the creatine kinase M isozyme (CKM). Under these conditions,
Simvastatin suppresses the differentiation of C2C12 myoblast cells via a Rac pathway
β Scribed by Tomomi T. Baba; Takayuki K. Nemoto; Toshihiro Miyazaki; Shinichiro Oida
- Book ID
- 106449370
- Publisher
- Springer Netherlands
- Year
- 2008
- Tongue
- English
- Weight
- 435 KB
- Volume
- 29
- Category
- Article
- ISSN
- 0142-4319
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract The transforming growth factor (TGF)βΞ² inducible early gene (TIEG)β1 is implicated in the control of cell proliferation, differentiation, and apoptosis in some cell types. Since TIEG1 functioning may be associated with TGFβΞ², a suppressor of myogenesis, TIEG1 is also likely to be involv
Ageing skeletal muscle displays declines in size, strength, and functional capacity. Given the acknowledged role that the systemic environment plays in reduced regeneration (Conboy et al. [2005] Nature 433: 760-764), the role of resident satellite cells (termed myoblasts upon activation) is relative
## Abstract Myostatin is a negative regulator of skeletal muscle mass. The pathways employed in modulating myostatin gene expression are scarcely known. We aimed to determine the signaling pathway of myostatin induction by a histone deacetylase (HDAC) inhibitorβtrichostatin A (TSA) in differentiate