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Simvastatin protects neurons from cytotoxicity by up-regulating Bcl-2 mRNA and protein

✍ Scribed by Leslie N. Johnson-Anuna; Gunter P. Eckert; Cornelia Franke; Urule Igbavboa; Walter E. Müller; W. Gibson Wood


Book ID
111179981
Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
677 KB
Volume
101
Category
Article
ISSN
0022-3042

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✍ Tong-Chun Wen; Yasutaka Sadamoto; Junya Tanaka; Peng-Xiang Zhu; Kimihiko Nakata; 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 467 KB

## Abstract Erythropoietin (EPO) promotes neuronal survival after cerebral ischemia in vivo and after hypoxia in vitro. However, the mechanisms underlying the protective effects of EPO on ischemic/hypoxic neurons are not fully understood. The present in vitro experiments showed that EPO attenuated