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Simvastatin and lovastatin, but not pravastatin, interact with MDR1

✍ Scribed by Toshiyuki Sakaeda; Kohji Takara; Mikio Kakumoto; Nobuko Ohmoto; Tsutomu Nakamura; Koichi Iwaki; Yusuke Tanigawara; Katsuhiko Okumura


Book ID
111768901
Publisher
Pharmaceutical Press
Year
2002
Tongue
English
Weight
173 KB
Volume
54
Category
Article
ISSN
2042-7158

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## Abstract Recent studies have shown that statins, the most potent inhibitors of 3‐hydroxy‐2‐methylglutaryl coenzyme A (HMG‐CoA) reductase, stimulate bone formation in vitro and in rodents by activating the expression of bone morphogenetic protein‐2 (BMP‐2), one of the most critical osteoblast dif