Simultaneous quantitative cassette analysis of drugs and detection of their metabolites by high performance liquid chromatography/ion trap mass spectrometry

Liquid chromatography tandem mass spectr

Liquid chromatography tandem mass spectrometric quantitation of sulfamethazine and its metabolites: direct analysis of swine urine by triple quadrupole and by ion trap mass spectrometry

✍ Gianluca Bartolucci; Giuseppe Pieraccini; Fabio Villanelli; Gloriano Moneti; Ant 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 75 KB 👁 2 views

This work describes a new method for the quantitation of trace amounts of sulfamethazine (SMZ) and its main metabolite, N4-acetylsulfamethazine (Ac-SMZ), in swine urine, using high-performance liquid chromatography (HPLC) tandem mass spectrometric analysis of crude urine after addition of internal s

Analysis of a commercial preparation of

Analysis of a commercial preparation of erythromycin estolates by tandem mass spectrometry and high performance liquid chromatography/electrospray ionization tandem mass spectrometry using an ion trap mass spectrometer

✍ Chien-Chen Lai; Pei-Lun Tsai; Cheng Yu; Guor-Rong Her 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 114 KB 👁 2 views

Because of the lack of a UV chromophore and their much smaller abundances in comparison with the major component, the minor components in erythromycin estolate preparations are difficult to analyze by high performance liquid chromatography ultraviolet (HPLC-UV). Tentative assignment of the major and

Isolation of circulating metabolites in

Isolation of circulating metabolites in drug discovery using high-performance liquid chromatography, and their identification by liquid chromatography coupled with tandem mass spectrometry and nuclear magnetic resonance spectroscopy

✍ Hong Kim; Wenqing Feng; Tze-Ming Chan; Diane Rindgen; Matthew Bryant; Kathleen A 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 221 KB 👁 2 views

Isolation of circulating metabolites in drug discovery using high-performance liquid chromatography, and their identification by liquid chromatography coupled with tandem mass spectrometry and nuclear magnetic resonance spectroscopy One of the major components of modern drug discovery is the structu

A simple liquid–liquid extraction with h

A simple liquid–liquid extraction with hexane for low-picogram determination of drugs and their metabolites in plasma by high-performance liquid chromatography with positive ion electrospray tandem mass spectrometry

✍ Yuan-Qing Xia; Daisy B. Whigan; Mohammed Jemal 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 246 KB 👁 2 views

Four sensitive, specific and accurate methods, based on high-performance liquid chromatography (HPLC) with positive ion electrospray tandem mass spectrometry (MS/MS) coupled with liquid-liquid extraction (LLE), have been developed and validated for the low-picogram determination of two drug candidat

Quantitative Analysis of Mevinolinic Aci

Quantitative Analysis of Mevinolinic Acid in Human Plasma by High-performance Liquid Chromatography Coupled with Negative-ion Electrospray Tandem Mass Spectrometry

✍ R. E. Calaf; M. Carrascal; E. Gelpí; J. Abian 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 136 KB 👁 2 views

Mevinolinic acid (MVA), the major active metabolite of Lovastatin in human blood, is analysed by microbore high-performance liquid chromatography coupled to electrospray tandem mass spectrometry. Quantification is carried out by using methylmevinolinic acid (MMVA) as internal standard. Positive-and

Qualitative and Quantitative Analyses of

Qualitative and Quantitative Analyses of Phenolic Compounds by High-performance Liquid Chromatography and Detection with Atmospheric Pressure Chemical Ionization Mass Spectrometry

✍ Maria Angeles Aramendía; Víctor Boráu; Isabel García; César Jiménez; Fernando La 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 English ⚖ 495 KB 👁 2 views

High-performance liquid chromatography with atmospheric pressure chemical ionization mass spectrometry (APCI-MS) in the negative-ion mode has been succesfuly used for qualitative and quantitative determination of phenolic compounds found in olive miU wastewater. APCl gives information about both the