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Simultaneous quantification of oxysophocarpine and its active metabolite sophocarpine in rat plasma by liquid chromatography/mass spectrometry for a pharmacokinetic study

✍ Scribed by Su-Jun Wang; Min Yang; Xiao-Tian Li; Guang-Ji Wang

Publisher: John Wiley and Sons
Year: 2007
Tongue: English
Weight: 180 KB
Volume: 21
Category: Article
ISSN: 0269-3879
DOI: 10.1002/bmc.820

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## Abstract A rapid, sensitive, and simple ultra‐performance liquid chromatography–tandem mass spectrometry (UPLC/MS/MS) method for the determination of udenafil and its active metabolite, DA‐8164, in human plasma and urine using sildenafil as an internal standard (IS) was developed and validated.