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Simultaneous quantification of ethylpurine adducts in human urine by stable isotope dilution nanoflow liquid chromatography nanospray ionization tandem mass spectrometry

โœ Scribed by Chen, Hauh-Jyun Candy; Lin, Chao-Ray


Book ID
122113728
Publisher
Elsevier Science
Year
2013
Tongue
English
Weight
780 KB
Volume
1322
Category
Article
ISSN
1873-3778

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## Abstract __N__โ€acetylaspartic acid (NAA) is a specific urinary marker for Canavan disease, an autosomal recessive leukodystrophy. We developed a โ€˜dilute and shootโ€™ stable isotope dilution liquid chromatography tandem mass spectrometry (LCโ€MS/MS) method for determination of NAA in urine. Deuterat