Simultaneous occurrence of tetrasomy 21 and trisomy 8 in a patient with early blastic metamorphosis of chronic myeloproliferative disorder

✍ Scribed by Lucia Sebastio; Dr. Felicetto Ferrara; Laura Vicari; Rosella Di Noto; Luigi Del Vecchio; Fabrizio Pane; Alfredo Fasanaro; Renato Cimino; Francesco Salvatore; Valerio Ventruto

• Publisher: John Wiley and Sons
• Year: 1995
• Tongue: English
• Weight: 763 KB
• Volume: 50
• Category: Article
• ISSN: 0361-8609
• DOI: 10.1002/ajh.2830500110

✦ Synopsis

Abstract

We report an unusual hyperdiploid karyotype characterized by the simultaneous occurrence of tetrasomy 21 and trisomy 8 detected during early blastic evolution of a BCR‐ABL‐negative chronic myeloproliferative disorder. Blast cells from this patient showed a striking response to all‐trans‐retinoic acid (ATRA)‐induced differentiation as evaluated by CD15 expression following in vitro exposure to this inducer. Our report represents the first description of such a composite karyotype in human hematologic malignancies.