Simultaneous occurrence of perimembranous glomerulonephritis and glomerular amyloidosis

✍ Scribed by A. Bohle; H. Fischbach; H. -V. GÄrtner; H. v. Gise; U. Helmchen; K. Potjan; E. Wildhirt

• Publisher: Springer
• Year: 1978
• Tongue: English
• Weight: 894 KB
• Volume: 378
• Category: Article
• ISSN: 1432-2307
• DOI: 10.1007/bf00465597

✦ Synopsis

The results of electron microscopic examination of renal biopsies from 3 patients with rheumatoid arthritis treated with penicillamine are presented. All 3 patients developed a nephrotic syndrome upon discontinuation of penicillamine therapy. When viewed with the electron microscope, segmental forms of perimembranous glomerulonephritis (Stages I-II of Ehrenreich and Churg) and glomerular renal amyloidosis Grade I-III were observed. In all three cases the nephrotic syndrome was considered to be due to the simultaneous occurrence of the two disease processes. In 2 cases perimembranous glomerulonephritis with immuno-complex-deposits was assumed to be the dominant factor in the causation of the disease, in the other case amyloidosis was the principle abnormality.