Simultaneous myocardial strain and dark-blood perfusion imaging using a displacement-encoded MRI pulse sequence
✍ Scribed by Yuan Le; Ashley Stein; Colin Berry; Peter Kellman; Eric E. Bennett; Joni Taylor; Katherine Lucas; Rael Kopace; Christophe Chefd'Hotel; Christine H. Lorenz; Pierre Croisille; Han Wen
- Publisher
- John Wiley and Sons
- Year
- 2010
- Tongue
- English
- Weight
- 692 KB
- Volume
- 64
- Category
- Article
- ISSN
- 0740-3194
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✦ Synopsis
Abstract
The purpose of this study is to develop and evaluate a displacement‐encoded pulse sequence for simultaneous perfusion and strain imaging. Displacement‐encoded images in two to three myocardial slices were repeatedly acquired using a single‐shot pulse sequence for 3 to 4 min, which covers a bolus infusion of Gadolinium contrast. The magnitudes of the images were T~1~ weighted and provided quantitative measures of perfusion, while the phase maps yielded strain measurements. In an acute coronary occlusion swine protocol (n = 9), segmental perfusion measurements were validated against microsphere reference standard with a linear regression (slope 0.986, R^2^ = 0.765, Bland‐Altman standard deviation = 0.15 mL/min/g). In a group of ST‐elevation myocardial infarction patients (n = 11), the scan success rate was 76%. Short‐term contrast washout rate and perfusion are highly correlated (R^2^ = 0.72), and the pixelwise relationship between circumferential strain and perfusion was better described with a sigmoidal Hill curve than linear functions. This study demonstrates the feasibility of measuring strain and perfusion from a single set of images. Magn Reson Med, 2010. © 2010 Wiley‐Liss, Inc.