Simultaneous monitoring of bemoradan pharmacokinetics and hemodynamics in mongrel dogs

✍ Scribed by Dr. Shiew-Mei Huang; Robert Falotico; Barbara Haertlein; Ian L. Smith

• Book ID: 101702583
• Publisher: John Wiley and Sons
• Year: 1992
• Tongue: English
• Weight: 411 KB
• Volume: 13
• Category: Article
• ISSN: 0142-2782
• DOI: 10.1002/bdd.2510130707

✦ Synopsis

This study was designed to determine the relationship between the hemodynamic responses to bemoradan, a novel cardiotonic agent, and its plasma levels after single administration of an oral dose or a 15 minute i.v. infusion to mongrel dogs, and to demonstrate that the clinical capsule formulation of bemoradan elicits a pharmacological response in the dog. Four conscious, instrumented mongrel dogs received each of four bemoradan treatments (30pg kg-l i.v., 100Fg kg-l i.v., 100pg kg-' suspension P.o., or 1 mg capsule p.0.) in a Latin square cross-over design. Plasma levels of bemoradan up to 24 h post-dosing were determined by HPLC. Cardiac contractility (dP/dt), heart rate, and arterial blood pressure were continuously monitored for 8 h and again at 24 h. Results of the study indicate that there was a significant correlation between bemoradan plasma levels and dP/dt. The 1 mg clinical capsule formulation was well absorbed when compared to an oral suspension and an i.v. dose. Peak increases in dP/dt of 64 per cent at 15 min for the suspension and 53 per cent at 1 h for the capsule were observed.