Simultaneous metabolism of aspirin and acetaminophen in man

✍ Scribed by Lewis P. Amsel; Clarke Davison

• Publisher: John Wiley and Sons
• Year: 1972
• Tongue: English
• Weight: 237 KB
• Volume: 61
• Category: Article
• ISSN: 0022-3549
• DOI: 10.1002/jps.2600610929

✦ Synopsis

0 Aspirin, administered orally in a single dose (2.9 8.) 1 hr. before 650 mg. acetaminophen, had no effect on the formation of the glucuronide and sulfate of acetaminophen. When aspirin was administered on a multiple-dose regimen of 2.6 g. daily for 3 days, followed by a 650-mg. dose of acetaminophen on the 4th day, there was likewise no effect on the formation of acetaminophen metabolites. Since large doses of aspirin have no apparent effect on acetaminophen metabolism, it appears these two drugs may be metabolized by different enzyme systems.

Keyphrases 0 Aspirin, metabolism-effect of subsequent acetaminophen administration, enzyme systems involved, man 0 Acetaminophen, metabolism-effect of prior aspirin administration, enzyme systems involved, man 0 Analgesics-simultaneous metabolism of aspirin and acetaminophen, man