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Simultaneous measurement of two cellular antigens and DNA using fluorescein-isothiocyanate, R-phycoerythrin, and propidium iodide on a standard FACScan

✍ Scribed by Willem E. Corver; Cees J. Cornelisse; Gert Jan Fleuren


Publisher
John Wiley and Sons
Year
1994
Tongue
English
Weight
964 KB
Volume
15
Category
Article
ISSN
0196-4763

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✦ Synopsis


Multiparameter flow cytometry is a powerful tool for analyzing the phenotypic, cell kinetic, and ploidy heterogeneity of tumor cell populations. Because of the substantial spectral overlap of propidium iodide (PI) and R-phycoerythrin (PE) fluorescence emission, this combined use of these fluorochromes has been thought not to be feasible on a standard flow cytometer for these kind of studies. Instead of PI, 7-amino-actinomy-