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Simultaneous measurement of plasma and brain extracellular fluid concentrations of catechols after yohimbine administration in rats

✍ Scribed by Katalin Szemeredi; Samuel Komoly; Irwin J. Kopin; Gyorgy Bagdy; Harry R. Keiser; David S. Goldstein

Book ID: 115801967
Publisher: Elsevier Science
Year: 1991
Tongue: English
Weight: 596 KB
Volume: 542
Category: Article
ISSN: 0006-8993
DOI: 10.1016/0006-8993(91)90990-d

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## Abstract The aim of this study was to investigate the pharmacokinetic behavior of huperzine A (Hup A) in plasma and cerebrospinal fluid (CSF) after intranasal administration (0.5 mg/kg) in male Sprague‐Dawley rats. A pharmacokinetic study of intravenous Hup A (0.5 mg/kg) was also performed. The