The aim of this study was to determine whether the micronucleus test, using the larvae of a lower invertebrate, the newt Pleurodeles waltl, is suitable for evaluating the overall genotoxicity of polluted water (AFNOR Standard, 1992). The study used the pollutant model benzo(a)pyrene (BaP). After hav
Simultaneous measurement of benzo[a]pyrene-induced Pig-a and lacZ mutations, micronuclei and dna adducts in mutaTMmouse
β Scribed by Christine L. Lemieux; George R. Douglas; John Gingerich; Souk Phonethepswath; Dorothea K Torous; Stephen D. Dertinger; David H. Phillips; Volker M. Arlt; Paul A. White
- Publisher
- John Wiley and Sons
- Year
- 2011
- Tongue
- English
- Weight
- 309 KB
- Volume
- 52
- Category
- Article
- ISSN
- 0893-6692
- DOI
- 10.1002/em.20688
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
The evaluation of the relationship between the dose to DNA of a genotoxic carcinogen and in vivo somatic cell mutagenesis may provide important information on the mechanisms leading to induced mutational events. The induction of DNA adducts and DNA mutations in different tissues of lacZ plasmid-base
DNA adducts are mainly detected by 32 P-postlabeling and enzyme-linked immunosorbent assays. We have established a method for detection of benzo[a]pyrene-diol-epoxide (BPDE)-DNA adducts by flow cytometry, and have clarified the effects of the DNA adducts on cell-cycle progression and the relationshi
XPA-deficient mice have a complete deficiency in nucleotide excision repair, and as such they display a cancer predisposition after exposure to several carcinogens. Besides being sensitive to genotoxic agents applied to the skin, they are also susceptible to human carcinogens given orally, like benz