Simultaneous magnetoencephalography and SQUID detected nuclear MR in microtesla magnetic fields

✍ Scribed by Petr Volegov; Andrei N. Matlachov; Michelle A. Espy; John S. George; Robert H. Kraus Jr.

• Book ID: 102953766
• Publisher: John Wiley and Sons
• Year: 2004
• Tongue: English
• Weight: 512 KB
• Volume: 52
• Category: Article
• ISSN: 0740-3194
• DOI: 10.1002/mrm.20193

✦ Synopsis

Abstract

A system that simultaneously measures magnetoencephalography (MEG) and nuclear magnetic resonance (NMR) signals from the human brain was designed and fabricated. A superconducting quantum interference device (SQUID) sensor coupled to a gradiometer pickup coil was used to measure the NMR and MEG signals. ^1^H NMR spectra with typical Larmor frequencies from 100–1000 Hz acquired simultaneously with the evoked MEG response from a stimulus to the median nerve are reported. The single SQUID gradiometer was placed approximately over the somatosensory cortex of a human subject to noninvasively record the signals. These measurements demonstrate, for the first time, the feasibility of simultaneous MRI and MEG. NMR in the microtesla regime provides narrow linewidths and the potential for high spatial resolution imaging, while SQUID sensors enable direct measurement of neuronal activity with high temporal resolution via MEG. Magn Reson Med 52:467–470, 2004. © 2004 Wiley‐Liss, Inc.