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Simultaneous knock-down of Bcl-xl and Mcl-1 induces pancreatic cancer apoptosis in vitro and in vivo

✍ Scribed by Takahashi, Hiroki; Matsuo, Yoichi; Takeyama, Hiromitsu; Eibl, Guido


Book ID
122123347
Publisher
S. Karger AG
Year
2013
Tongue
English
Weight
53 KB
Volume
13
Category
Article
ISSN
1424-3903

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## Abstract In ovarian carcinomas, recurrence and acquired chemoresistance are the first leading causes of therapeutic failure and are responsible for the poor overall survival rate. Cisplatin exposure of sensitive cells has been previously associated with a down‐regulation of Bcl‐X~L~ expression a