Simultaneous infusions of parenteral opioids with epidural local anaesthetics

Midazolam improves postoperative epidura

Midazolam improves postoperative epidural analgesia with continuous infusion of local anaesthetics

✍ Tomoki Nishiyama; Takeshi Yokoyama; Kazuo Hanaoka 📂 Article 📅 1998 🏛 Springer-Verlag 🌐 French ⚖ 527 KB

Pharmacokinetics of epidurally administe

Pharmacokinetics of epidurally administered nicomorphine with its metabolites and glucuronide conjugates in patients undergoing pulmonary surgery during combined epidural local anaesthetic block and general anaesthesia

✍ Petronella M. Koopman-Kimenai; Tom B. Vree; Leo H. D. J. Booij; Marcel A. W. M. 📂 Article 📅 1995 🏛 John Wiley and Sons 🌐 English ⚖ 701 KB

After epidural administration of 15 mg 3,6-dinicotinoylmorphine (nicomorphine) in 10 patients undergoing pulmonary surgery, the parent compound was quickly metabolized into the metabolites 6-mononicotinoylmorphine and morphine. The mean apparent half-lives ( f SD) of elimination were 10min (0.165 h