Simultaneous homoharringtonine and interferon-α in the treatment of patients with chronic-phase chronic myelogenous leukemia
✍ Scribed by Susan O'Brien; Moshe Talpaz; Jorge Cortes; Jianqin Shan; Francis J. Giles; Stefan Faderl; Deborah Thomas; Guillermo Garcia-Manero; Susie Mallard; Mary Beth Rios; Charles Koller; Steve Kornblau; Michael Andreeff; Anthony Murgo; Michael Keating; Hagop M. Kantarjian
- Publisher
- John Wiley and Sons
- Year
- 2002
- Tongue
- English
- Weight
- 110 KB
- Volume
- 94
- Category
- Article
- ISSN
- 0008-543X
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## Abstract ## BACKGROUND Before the discovery of imatinib mesylate, a Bcr‐Abl selective tyrosine kinase inhibitor, three agents, interferon‐alpha (IFN‐α), cytarabine (ara‐C), and homoharringtonine (HHT), had demonstrated activity against Philadelphia chromosome (Ph)‐positive chronic myelogenous l
A patient with Philadelphia-positive (Ph+) chronic myelogenous leukemia (CML) was diagnosed with cutaneous sarcoidosis after treatment with interferon-alpha (IFN-␣). Following IFN-␣ dose reduction, the skin lesions disappeared. Few cases of sarcoidosis associated with IFN treatment have been reporte