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Simultaneous determination of yohimbine, sildenafil, vardenafil and tadalafil in dietary supplements using high-performance liquid chromatography-tandem mass spectrometry

✍ Scribed by Ying Zhang; Zhiqiang Huang; Li Ding; Hongfei Yan; Meiling Wang; Shaohua Zhu

Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
150 KB
Volume
33
Category
Article
ISSN
1615-9306

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✦ Synopsis

Abstract

A simple and sensitive method was developed for determination of illegal adulterants (yohimbine, sildenafil, vardenafil and tadalafil) in dietary supplements by HPLC‐MS/MS. The separation was achieved on a C~18~ column with the mobile phase consisting of acetonitrile and 0.1% acetic acid aqueous solution with a gradient elution at a flow rate of 0.5 mL/min. The analytes were quantified and identified by two characteristic transitions using the multiple‐reaction monitoring mode. The recoveries of the analytes ranged from 77.5 to 109.3% with the RSD less than 8.1% (n=6). The method has been successfully applied to screen illegal adulterations of natural dietary supplements.

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