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Simultaneous determination of macrolides, sulfonamides, and other pharmaceuticals in water samples by solid-phase extraction and LC-(ESI) MS

✍ Scribed by Marta Pedrouzo; Francesc Borrull; Rosa Maria Marcé; Eva Pocurull

Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
468 KB
Volume
31
Category
Article
ISSN
1615-9306

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✦ Synopsis

Abstract

This paper describes a method for determining 11 pharmaceuticals in various water sources by SPE followed by LC‐(ESI) MS. SPE was carried out with Oasis^TM^ HLB and the recoveries were 33–67% for 250 and 100 mL sewage water, 55–77% for 500 mL river water and 72–98% for 1 L tap water, with the exception of sulfamethoxazole and omeprazole which showed lower recoveries in all kinds of sample. The LODs in river water were of 5 ng/L for sulfadiazine, trimethoprim, sulfamethazine, sulfamethoxazole, and ranitidine and 10 ng/L for the other compounds. The highest concentrations found in river waters were for sulfamethoxazole (50 ng/L). In influent sewage waters, ranitidine was the most commonly detected compound with a maximum value of 0.24 μg/L.

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