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Simultaneous determination of kynurenine and kynurenic acid concentrations in human serum by HPLC with dual wavelengths fluorescence detection

✍ Scribed by Le-Dong Xiao; Xi-Bo Luo; Lan-Gan Pi; Ai-Guo Tang


Book ID
116347964
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
233 KB
Volume
395
Category
Article
ISSN
0009-8981

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## Abstract Kynurenic acid (KYNA), one of the tryptophan metabolites, serves as an endogenous antagonist of __N__‐methyl‐d‐aspartate and the __α__7 nicotinic receptors in mammalian brains. In the present study, the column‐switching high‐performance liquid chromatography (HPLC) method we developed f