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Simultaneous determination of irbesartan and hydrochlorothiazide in human plasma by ultra high performance liquid chromatography tandem mass spectrometry and its application to a bioequivalence study

✍ Scribed by Qiu, Xiangjun; Wang, Zhe; Wang, Bing; Zhan, Hui; Pan, Xiaofeng; Xu, Ren-ai


Book ID
125459015
Publisher
Elsevier Science
Year
2014
Tongue
English
Weight
826 KB
Volume
957
Category
Article
ISSN
1873-376X

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## Abstract A method based on liquid chromatography with negative ion electrospray ionization and tandem mass spectrometry is described for the determination of nimesulide in human plasma. Liquid–liquid extraction using a mixture of diethyl ether and dichloromethane was employed and celecoxib was u