โ Scribed by D.J. Pritchard; H. Morgan; J.M. Cooper
No coin nor oath required. For personal study only.
A technique is described for constructing a multianalyte immunosensor for the quantitative determination of the human gonadotrophin hormones follicle stimulating hormone (FSH) and luteinising hormone (LH). The assay is a based upon the electrochemical detection of two horseradish peroxidase labelled antibodies using a ferrocene mediated system. The detection limits (3~) were 2.1 U 1-l FSH and 1.8 U 1-l LH. There was negligible cross reactivity. Results obtained with the biosensor showed a good correlation with those obtained using an established clinical diagnostic technique based upon dissociation-enhanced lanthanide fluorometric immunoassay. This is the first report of an electrochemical multianalyte immunosensor for high molecular weight analytes.
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Immunoreactive follicle-stimulating hormone (IR-FSH) is detected in sections of formalin-fixed and paraffln-embedded gastric mucosal tissue of normal men, using the immunoperoxidase staining technique and specific antisera to hFSH (NIDDK, NIH). Positive staining for IR-FSH was detected in the pariet
## Abstract __A series of homoโ and heterodimeric compounds encompassing the follicleโstimulating hormone receptor (FSHR) antagonist (__R__)โ1 and its inactive conformer (__S__)โ1 connected through ethylene glycol spacers of various lengths is described. Evaluation of these compounds reveals that d