A simple and sensitive HPLC method has been developed for the simultaneous determination of enrofloxacin (ENR) and ciprofloxacin (CIP) in plasma. Plasma sample preparation was carried out by adding phosphate buffer (pH 7.4, 0.1 M), followed by extraction with trichloromethane. ENR, CIP and the inter
β¦ LIBER β¦
Simultaneous determination of enrofloxacin and its primary metabolite ciprofloxacin in bovine milk and plasma by ion-pairing liquid chromatography
β Scribed by Krystyna L. Tyczkowska; Robert D. Voyksner; Kevin L. Anderson; Mark G. Papich
- Publisher
- Elsevier Science
- Year
- 1994
- Weight
- 577 KB
- Volume
- 658
- Category
- Article
- ISSN
- 0378-4347
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## Abstract A new liquid chromatographyβmass spectrometry (LCβMS) method has been developed and validated for the simultaneous determination of eight quinolone antibacterials for veterinary use in processed bovine milk samples. The quinolones studied included marbofloxacin, ciprofloxacin, danofloxa