✦ LIBER ✦

Simultaneous determination of dimethylarsinic acid and monomethylarsonic acid after derivatization with thioglycol methylate by gas chromatography/mass spectrometry

✍ Scribed by Zoltán Mester; Gyula Horváth; György Vitányi; László Lelik; Péter Fodor

Publisher: John Wiley and Sons
Year: 1999
Tongue: English
Weight: 120 KB
Volume: 13
Category: Article
ISSN: 0951-4198
DOI: 10.1002/(sici)1097-0231(19990315)13:5<350::aid-rcm490>3.0.co;2-v

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✦ Synopsis

A gas chromatography/mass spectrometry (GC/MS) method has been developed to determine two methylated arsenic species in human urine samples. The yield of derivatization for dimethylarsinic acid (DMA) and monomethylarsonic acid (MMA) using thioglycol methylate (TGM) was measured. The detection limit for the derivatized DMA and MMA using the GC/MS method are 0.95 and 0.8 ng cm À3 , respectively. This simple and rapid method has good precision and accuracy. Fragmentation routes of derivatized MMA and DMA are suggested on accurate mass measurements.

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