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Simultaneous determination of cephalexin and cefadroxil by using the coupling technique of synchronous fluorimetry and H-point standard additions method

✍ Scribed by Yang Jinghe; Zhou Guangjun; Jie Nianqin; Han Rongjiang; Lin Cunguo; Hu Jingtian

Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
518 KB
Volume
325
Category
Article
ISSN
0003-2670

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✦ Synopsis

The coupling technique of synchronous fluorimetry and the H-point standard additions method was applied to determine cephalexin and cefadroxil with symmetric and seriously overlapping spectra simultaneously. Under the optimum conditions, the linear determination ranges of cephalexin and cefadroxil are ca. 2.5 X 10-4-7.5 X 10V3 mg ml-' and ca. 1.0 X 10W4-5.0 X lop3 mg ml-', respectively. The results showed that cephalexin and cefadroxil can be determined simultaneously when the concentration ratio of cephalexin to cefadroxil vary from 1011 to 1:5 in the mixed sample. The accuracy and precision of the results are all satisfactory.

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