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Simultaneous Determination of Caffeine and Theophylline in Human Plasma with a Weak Cation Monolithic SPE-column

✍ Scribed by Tao Zhu; Kyung Ho Row


Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
103 KB
Volume
28
Category
Article
ISSN
0256-7660

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Simultaneous determination of theophylli
✍ Yu-Luan Chen; Heiko Junga; Xiangyu Jiang; Weng Naidong πŸ“‚ Article πŸ“… 2003 πŸ› John Wiley and Sons 🌐 English βš– 440 KB

## Abstract Theophylline, tolbutamide, mephenytoin, debrisoquin, and dapsone are marker substrates for CYP1A2, CYP2C9, CYP2C19, CYP2D6, and CYP3A4, respectively. A silica‐based monolithic column (Chromolith SpeedROD RP‐18e, 50Γ—4.6 mm) was used to separate these five marker substrates of cytochrome