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Simultaneous determination of apatinib and its four major metabolites in human plasma using liquid chromatography–tandem mass spectrometry and its application to a pharmacokinetic study

✍ Scribed by Juefang Ding; Xiaoyan Chen; Xiaojian Dai; Dafang Zhong

Book ID
113687713
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
754 KB
Volume
895-896
Category
Article
ISSN
1873-376X

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Simultaneous determination of apatinib a
Simultaneous determination of apatinib and its four major metabolites in human plasma using liquid chromatography–tandem mass spectrometry and its application to a pharmacokinetic study
✍ Juefang Ding; Xiaoyan Chen; Xiaojian Dai; Dafang Zhong 📂 Article 📅 2012 🏛 Elsevier Science 🌐 English ⚖ 754 KB

Apatinib, also known as YN968D1, is a novel antiangiogenic agent that selectively inhibits vascular endothelial growth factor receptor-2. Currently, apatinib is undergoing phase II/III clinical trials in China for the treatment of solid tumors. Apatinib is extensively metabolized in humans, and its