Simultaneous determination of amitriptyline, imipramine and perphenazine in pharmaceutical preparations and blood serum by multi-wavelength spectrophotometry
✍ Scribed by J.M. García Fraga; A.I. Jiménez Abizanda; F. Jiménez Moreno; J.J. Arias León
- Publisher
- Elsevier Science
- Year
- 1991
- Tongue
- English
- Weight
- 700 KB
- Volume
- 252
- Category
- Article
- ISSN
- 0003-2670
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✦ Synopsis
Several methods were developed for the simultaneous determination of the binary mixtures amitriptyline-imipramine (1.00-10 /~g ml-'). amitriptyline-perphenazine (1.00-30.00 and 1.00-8.00 pg ml-') and imipramine-perphenazinc (1.00-30.00 and 1.00-8.00 pg ml-') and the ternary mixture amitriptyline-perphenazine-imipkmine using a diode-array spectrophotometer and a multi-component analysis program. The m&hods were applied to the determinktion of the components of synthetic perphenazine-imipramine mixtures, real amitriptyline-imipramine and amiiriptyline-imipramine-perphenazine mixtures in blood serum and real amitriptyline-perphenazine mixtures in pharmaceutical preparations.