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Simulation of two-dimensional cell growth with application to tumor kinetics

✍ Scribed by W. Düchting; G. Dehl


Publisher
Elsevier Science
Year
1980
Tongue
English
Weight
768 KB
Volume
22
Category
Article
ISSN
0378-4754

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✦ Synopsis


The present paper tries to determine the spatial structure and the time behaviour of cell renewal systems. For this purpose a computer model for the two-dimensional cell space was developed, which is described by a set of specifications and growth statements.

Regarding the development of this model special emphasis was given to -the existence of several cell systems with different mean life spans, -the variability of the initial configuration of cell patterns, -the description of cell-to-cell interactions, -the perturbation of normal cell growth by tumor cells and their elimination, in medicine comparable with a removal by surgery or by irradiation, -the consideration of the loss of tumor cells, In the future it seems to be possible to partly substitute long and expensive biological experimental test series by simulation with the help of these models.


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