✦ LIBER ✦

Simulation of epileptiform activity in the hippocampus using transputers

✍ Scribed by J.B. Willis; Y.C. Ge; H.V. Wheal

Publisher: Elsevier Science
Year: 1993
Tongue: English
Weight: 682 KB
Volume: 47
Category: Article
ISSN: 0165-0270
DOI: 10.1016/0165-0270(93)90083-4

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Noradrenergic modulation of epileptiform

Noradrenergic modulation of epileptiform activity in the hippocampus

✍ Paul A. Rutecki 📂 Article 📅 1995 🏛 Elsevier Science 🌐 English ⚖ 852 KB

Norepinephrine has been proposed to have both pro- and anticonvulsant properties. In the CA3 region of rat hippocampal slices, we studied the effects of norepinephrine and selective adrenergic agonists and antagonists on spontaneously occurring epileptiform discharges produced by either picrotoxin,

Docosahexaenoic acid inhibits synaptic t

Docosahexaenoic acid inhibits synaptic transmission and epileptiform activity in the rat hippocampus

✍ Chainllie Young; Po-Wu Gean; Lih-Chu Chiou; Yu-Zen Shen 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 103 KB 👁 1 views

Docosahexaenoic acid (DHA) has been suggested to be required for neuronal development and synaptic plasticity. However, in view of the fact that DHA facilitates NMDA responses and blocks K(+) channels, it might predispose the neurons to epileptiform bursting. By using extracellular recording of popu

Simulations of epileptiform activity in

Simulations of epileptiform activity in the hippocampal CA3 region in vitro

✍ Roger D. Traub; John G. R. Jefferys 📂 Article 📅 1994 🏛 John Wiley and Sons 🌐 English ⚖ 522 KB

The hippocampus is one of the most seizure-prone regions of the central nervous system. Indeed, even in hippocampal slices, epileptiform activity can be easily induced by pharmacological blockade of GABAA receptors. The resulting activity consists of one or more synchronized population bursts that a

Inwardly rectifying K+ (Kir) channels an

Inwardly rectifying K+ (Kir) channels antagonize ictal-like epileptiform activity in area CA1 of the rat hippocampus

✍ Mogens Andreasen; Jane Skov; Steen Nedergaard 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 493 KB 👁 1 views

## Abstract Reactive glial cells, for example, from patients with temporal lope epilepsy have a reduced density of inward rectifying K^+^ (Kir) channels and thus a reduced K^+^ buffering capacity. Evidence is accumulating that this downregulation of Kir channels could be implicated in epileptogenes

Effects of antiepileptic drugs on 4-amin

Effects of antiepileptic drugs on 4-aminopyridine-induced epileptiform activity in young and adult rat hippocampus

✍ Yukiko Fueta; Massimo Avoli 📂 Article 📅 1992 🏛 Elsevier Science 🌐 English ⚖ 843 KB

Extracellular field potential recordings were used to study the effects of the antiepileptic drugs (AEDs) carbamazepine (CBZ), phenytoin (PHT), phenobarbital (PhB) and valproic acid (VPA) on the epileptiform activity evoked by 4-aminopyridine (4-AP, 50 microM) in the CA3 subfield of rat hippocampal

Hypoosmolar conditions reduce extracellu

Hypoosmolar conditions reduce extracellular volume fraction and enhance epileptiform activity in the CA3 region of the immature rat hippocampus

✍ Werner Kilb; Paul W. Dierkes; Eva Syková; Lydia Vargová; Heiko J. Luhmann 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 536 KB

## Abstract The osmolarity of the extracellular space (ECS) compartment is an important factor determining the excitability of neuronal tissue. In the adult hippocampus an important role of osmolarity and ECS diffusion parameters on the susceptibility to epileptic events is well established, but th