Correlation between rate of enzyme-subst
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Huan-Xiang Zhou; James M. Briggs; Sylvia Tara; J. Andrew McCammon
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Article
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1998
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Wiley (John Wiley & Sons)
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English
⚖ 107 KB
The utility of the average Boltzmann factor around the active site of an enzyme as the predictor of the electrostatic enhancement of the substrate binding rate is tested on a set of data on wild-type acetylcholinesterase and 18 charge mutants recently obtained by Brownian dynamics simulations. A goo