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Simulation of drug dynamic parameters and optimization models of the functional respiratory system in pharmacokinetic studies

✍ Scribed by Kostyantyn Polinkevych; Galyna Onopchuk; Stanislav Polinkevych

Book ID
108216244
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
697 KB
Volume
71
Category
Article
ISSN
0362-546X

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Assessment of input function distortions
Assessment of input function distortions on kinetic model parameters in simulated dynamic 82Rb PET perfusion studies
✍ Carsten Meyer; Dragoş-Nicolae Peligrad; Martin Weibrecht πŸ“‚ Article πŸ“… 2007 πŸ› Elsevier Science 🌐 English βš– 170 KB

Cardiac 82 rubidium dynamic PET studies allow quantifying absolute myocardial perfusion by using tracer kinetic modeling. Here, the accurate measurement of the input function, i.e. the tracer concentration in blood plasma, is a major challenge. This measurement is deteriorated by inappropriate tempo