Simulation of a common oligogenic disease with quantitative risk factors. GAW9 problem 2: The answers

✍ Scribed by Dr. Jean W. MacCluer; John Blangero; Thomas D. Dyer; Candace M. Kammerer

• Publisher: John Wiley and Sons
• Year: 1995
• Tongue: English
• Weight: 281 KB
• Volume: 12
• Category: Article
• ISSN: 0741-0395
• DOI: 10.1002/gepi.1370120629

✦ Synopsis

For Problem 2, simulated family data were provided for a common oligogenic disease that was defined by imposing a threshold, T, on a quantitative trait, 41.

Every individual with a value of Q1 > T (where T = 87.5) was defined as affected.

Participants were told that three other quantitative traits (42, 43, and 4 4 ) and an environmental factor (EF) also were thought to be associated with the disease as intervening variables, and that 12 candidate loci (C1 -C12) were postulated to influence traits associated with the disease. The tasks for GAW9 were to characterize the genetic and environmental contribution to Q1 (and the disease), 4 2 , 4 3 , and 44, and to localize any single genes that had detectable effects.