𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Simulation and optimisation of integrated bioprocesses: a case study

✍ Scribed by Y H Zhou; N J Titchener-Hooker

Publisher
Wiley (John Wiley & Sons)
Year
1999
Tongue
English
Weight
168 KB
Volume
74
Category
Article
ISSN
0268-2575

No coin nor oath required. For personal study only.

✦ Synopsis

Biotech companies need to reduce time to market and to raise the efficiency of processing in order to lower costs. This paper presents results of the application of computer-based simulations for the rapid formulation of integrated bioprocesses designs and demonstrates the use of simulations to explore the nature and impact of the interactions that exist in a typical bioprocess. An approach for the optimisation of such integrated bioprocesses is presented. Data from a continuous fermentation, with models for cell harvesting, cell disruption and cell debris removal, veriΓΌed by comparison with pilot-scale data, have been integrated and used to demonstrate the consequences of diΓΎ erent process designs and operating decisions on the resulting process performance.

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