Simulating Structural and Thermodynamic Properties of Carcinogen-Damaged DNA
โ Scribed by Yan, Shixiang; Wu, Min; Patel, Dinshaw J.; Geacintov, Nicholas E.; Broyde, Suse
- Book ID
- 118515758
- Publisher
- Biophysical Society
- Year
- 2003
- Tongue
- English
- Weight
- 924 KB
- Volume
- 84
- Category
- Article
- ISSN
- 0006-3495
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
To determine three-dimensional conformations of DNA damaged by environmental chemical carcinogens, effective molecular mechanics search techniques have been developed to deal with the large system sizes and computational demands. First, extensive surveys of the potential energy surface are carried o
We propose an index of DNA homogeneity (IDH) based on a binary distribution model that quantifies structural and thermodynamic aggregates present in DNA primary structures. Extensive analysis of sequence databases with the IDH uncovers significant constraints on DNA sequence other than those derived