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Simulating Linkage Disequilibrium Structures in a Human Population for SNP Association Studies

โœ Scribed by Xiguo Yuan; Junying Zhang; Yue Wang


Publisher
Springer
Year
2011
Tongue
English
Weight
651 KB
Volume
49
Category
Article
ISSN
0006-2928

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Linkage disequilibrium of MTHFR genotype
โœ Stegmann, Karolin; Ziegler, Andreas; Ngo, Ernestine T. K. M.; Kohlschmidt, Nicol ๐Ÿ“‚ Article ๐Ÿ“… 1999 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 32 KB ๐Ÿ‘ 1 views

A number of studies have demonstrated that the common polymorphism 677Cโ†’T in the gene encoding 5, 10-methylenetetrahydrofolate reductase (MTHFR) leads to a thermolabile variant with decreased enzyme activity and to mildly elevated plasma homocysteine. 677TT homozygosity was shown to be more frequent