Simply produced closed-head, focal lesions for study of repair in immature rat cerebral cortex
✍ Scribed by Lester M. Geller; David Cowen; Abner Wolf
- Publisher
- John Wiley and Sons
- Year
- 1970
- Tongue
- English
- Weight
- 496 KB
- Volume
- 3
- Category
- Article
- ISSN
- 0012-1630
No coin nor oath required. For personal study only.
✦ Synopsis
Multiple electroconvulsive shocks consistently and rapidly produce uniform, bilaterally symmetrical lesions in the immature rat's cerebral cortex, without the incidental damage that accompanies other experimental injuries to the central nervous system. The terminal lesion, devoid of nerve cells, is a narrow, laminar band of numerous myelinated axons, unaccompanied by a glial scar. Insofar as the initially damaged area becomes occupied by nerve fibers, the healing process may be thought of as involving a regeneration. A variety of studies for which the electroshock lesions might be used is suggested. closed-head, focal cerebral cortical lesions laminar cortical lesions healing in immature cerebral cortex regeneration in central nervous system electroshock infant rat axonal repopulation in injured cerebral cortex